Presentation is loading. Please wait.

Presentation is loading. Please wait.

Genetic ablation of genes encoding PI3K components blocked the prostate tumorigenesis caused by PTEN loss. Genetic ablation of genes encoding PI3K components.

Published bySudomo Lesmana Modified over 5 years ago

Similar presentations

Presentation on theme: "Genetic ablation of genes encoding PI3K components blocked the prostate tumorigenesis caused by PTEN loss. Genetic ablation of genes encoding PI3K components."— Presentation transcript:

1 Genetic ablation of genes encoding PI3K components blocked the prostate tumorigenesis caused by PTEN loss. Genetic ablation of genes encoding PI3K components blocked the prostate tumorigenesis caused by PTEN loss. A–E, in anterior prostate (AP) tumors, ablation of Pik3cb, not Pik3ca, impaired PTEN loss–induced tumorigenesis. F–I, in the VP, ablation of Pik3ca or Pik3cb failed to affect PTEN loss–induced tumorigenesis. J, concurrent ablation of both Pik3ca and Pik3cb restored the normal ductal structure of PTEN-null prostate tumors in the VP. HG-PIN lesions are labeled with an arrow, and regular ductal structure, labeled with arrowheads, feature a single epithelial layer, small amounts of stroma, and abundant secreted proteins. Prostates shown are from mice at the age of 12 weeks. Shidong Jia et al. Cancer Discovery 2013;3:44-51 ©2013 by American Association for Cancer Research

Download ppt "Genetic ablation of genes encoding PI3K components blocked the prostate tumorigenesis caused by PTEN loss. Genetic ablation of genes encoding PI3K components."

Similar presentations

ATM John Berry. What is ATM? Named “ATM” for “Ataxia-telangiectasia Mutated” gene. The mutation is recessive. Named “ATM” for “Ataxia-telangiectasia Mutated”

ATM John Berry. What is ATM? Named “ATM” for “Ataxia-telangiectasia Mutated” gene. The mutation is recessive. Named “ATM” for “Ataxia-telangiectasia Mutated”
Companion PowerPoint slide set Obesity-associated breast cancer risk: a role for epigenetics? This teacher slide set was created by Dana Haine, MS, of.

Companion PowerPoint slide set Obesity-associated breast cancer risk: a role for epigenetics? This teacher slide set was created by Dana Haine, MS, of.
Reduced Tumor Necrosis Factor-α and Transforming Growth Factor-β1 Expression in the Lungs of Inbred Mice that Fail to Develop Fibroproliferative Lesions.

Reduced Tumor Necrosis Factor-α and Transforming Growth Factor-β1 Expression in the Lungs of Inbred Mice that Fail to Develop Fibroproliferative Lesions.
Histogenic analysis confirms prostate cancer metastasis to lung.

Histogenic analysis confirms prostate cancer metastasis to lung.
Genetic alterations in the PI3K–PTEN–AKT pathway detected during disease progression and their functional impacts. Genetic alterations in the PI3K–PTEN–AKT.

Genetic alterations in the PI3K–PTEN–AKT pathway detected during disease progression and their functional impacts. Genetic alterations in the PI3K–PTEN–AKT.
Antiproliferative effects of erlotinib correlate poorly with abundance of p-EGFR. Antiproliferative effects of erlotinib correlate poorly with abundance.

Antiproliferative effects of erlotinib correlate poorly with abundance of p-EGFR. Antiproliferative effects of erlotinib correlate poorly with abundance.
Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity  Darren J. Baker,

Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity  Darren J. Baker,
PI3K isoform–selective inhibitors and PTEN induction decrease ERK phosphorylation. PI3K isoform–selective inhibitors and PTEN induction decrease ERK phosphorylation.

PI3K isoform–selective inhibitors and PTEN induction decrease ERK phosphorylation. PI3K isoform–selective inhibitors and PTEN induction decrease ERK phosphorylation.
Reginald Hill, Yurong Song, Robert D. Cardiff, Terry Van Dyke  Cell 

Reginald Hill, Yurong Song, Robert D. Cardiff, Terry Van Dyke  Cell 
PTEN Tumor Suppressor Extraordinaire

PTEN Tumor Suppressor Extraordinaire
IL6 secretion is a hallmark of postsenescence.

IL6 secretion is a hallmark of postsenescence.
Volume 4, Issue 3, Pages (September 2003)

Volume 4, Issue 3, Pages (September 2003)
Volume 15, Issue 2, Pages (February 2009)

Volume 15, Issue 2, Pages (February 2009)
Copy-number alterations in an archival breast cancer sample.

Copy-number alterations in an archival breast cancer sample.
High-throughput analysis of informative CpG sites for the four studied tumor suppressor genes (A-D). High-throughput analysis of informative CpG sites.

High-throughput analysis of informative CpG sites for the four studied tumor suppressor genes (A-D). High-throughput analysis of informative CpG sites.
Reduction of Sca-1 increases PPARγ expression.

Reduction of Sca-1 increases PPARγ expression.
Homeostasis in the breast

Homeostasis in the breast
Volume 19, Issue 6, Pages (June 2011)

Volume 19, Issue 6, Pages (June 2011)
Metformin decreases mTORC1 activity in the basal layer of oral epithelial dysplasias and mitotic activity in the hyperplastic epithelium. Metformin decreases.

Metformin decreases mTORC1 activity in the basal layer of oral epithelial dysplasias and mitotic activity in the hyperplastic epithelium. Metformin decreases.
Volume 128, Issue 4, Pages (April 2005)

Volume 128, Issue 4, Pages (April 2005)

Similar presentations

Ads by Google