1. The increased cytosolic and nuclear β-catenin in the tubular epithelial cells of 7-d obstructed kidneys is suppressed by recombinant sFRP4.
The increased cytosolic and nuclear β-catenin in the tubular epithelial cells of 7-d obstructed kidneys is suppressed by recombinant sFRP4. The red fluorescence represents β-catenin staining in the cortex (A, B, D, E, G, H, J, and K), and in the inner medullary regions (C, F, I, and L) of kidneys from normal (A through C), UUO 4 d (D through F), UUO 7 d with vehicle-treated (G through I), and UUO 7 d with sFRP4-treated (J through L) mice. The arrowheads point at tubular epithelial cells with increased cytosolic or nuclear β-catenin staining. The arrows point at interstitial cells with increased β-catenin staining.
Kameswaran Surendran et al. JASN 2005;16:
©2005 by American Society of Nephrology