1. mTORC1 activation and Myc expression signature in atypical cysts and neoplasms.A–O.Serial sections of a simple cyst (A,D,G,J,M) and two neoplasms (B,E,H,K,N and C,F,I,L,O) stained with H&E (A–C) or stained immunohistochemically for Ki67 (D–F), phospho‐Thr37/46‐4E‐BP1 (G–I), phospho‐Ser240/244‐ribosomal S6 protein (J–L) or Myc (M–O).
mTORC1 activation and Myc expression signature in atypical cysts and neoplasms.A–O.Serial sections of a simple cyst (A,D,G,J,M) and two neoplasms (B,E,H,K,N and C,F,I,L,O) stained with H&E (A–C) or stained immunohistochemically for Ki67 (D–F), phospho‐Thr37/46‐4E‐BP1 (G–I), phospho‐Ser240/244‐ribosomal S6 protein (J–L) or Myc (M–O). Dotted lines indicate the boundary of normal tissue and neoplasms.P.Quantification of the percentage of simple cysts (n = 68–185) or atypical cysts and neoplasms (n = 34–51) that display higher levels (strong) of staining than adjacent normal tissue in the same section (negative/weak).Q.Model summarising the proposed sequence of morphological and molecular alterations involved in formation of ccRCC. For details see the Discussion Section.
Joachim Albers et al. EMBO Mol Med. 2013;5:
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