1. Supp. Figure 1
MM-302
trastuzumab
Vessels
Hoechst
Merge

2. * p = 0.0189 * p = 0.0101 Supp. Figure 2 16 12 Percent injected
dox/gram tissue
MM-302
+ IgG
MM-302 +
T-DM1
PBS
trastuzumab
alone 16 12 4
* p = 8
* p =

3. time following injection (hrs)
Supp. Figure 3
MM-302 (3 mg/kg)
MM trastuzumab
ng dox/5mL plasma (log)
time following injection (hrs)

4. Supp. Figure 4 BT474-M3 NCI-N87 MM-302 + trast. Bliss additive value
MM-302 alone
trastuzumab alone
Time following first dose (days)
BT474-M3
NCI-N87
% tumor growth
inhibition
100 80 60 40 20 5 10 15 25 30 35