1. Fly culture
3주차

2. Drosophila as model species
Studied for ~100 years
Short life cycle
Small and easy to maintain and manipulate in the Lab (low cost)
Each female lays eggs
Simple karyotype : 4 pairs of large chromosomes (3 autosomes + sexual chromosomes)
Many available mutants
Gene sequence conservation with humans : 70%

3. Drosophila melanogaster is used to study
Embryonic development
Neurodegenerative
Diabetes
Aging
Drug abuse
Cancer
Microbiota

4. Life cycle
Growth Phase
10 25℃
20 18℃
Stages

5. Sexing Drosophila Females larger than males
Males – dorsal posterior plates are black
Females – only last plate is dark

6. Sexing Drosophila Males – visible genitals Females not as visible
Males – sex combs
Females – lack sex combs