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The role of the mast cell in the pathophysiology of asthma

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1 The role of the mast cell in the pathophysiology of asthma
Peter Bradding, DM, Andrew F. Walls, PhD, Stephen T. Holgate, MD, DSc  Journal of Allergy and Clinical Immunology  Volume 117, Issue 6, Pages (June 2006) DOI: /j.jaci Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 An electron micrograph of an activated mast cell in the airway mucosa of a subject with asthma. There is variable loss of granule contents (arrowheads) although granule membranes (arrows) remain intact, a process known as piecemeal degranulation. Magnification ×6000. Picture courtesy of Dr Susan Wilson. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 A, A 2-μm section of bronchus from a patient with asthma demonstrating the presence of degranulated tryptase+ mast cells (arrows) within an ASM bundle. B, Numbers of mast cell within the bronchial smooth muscle bundles of normal subjects and patients with asthma and eosinophilic bronchitis. Copyright © 2002 Massachusetts Medical Society. All rights reserved. Reproduced with permission.9 C, IL-4+ mast cells (arrows) within an ASM bundle. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

4 Fig 3 Photomicrograph of tryptase+ mast cells (arrows) within the airway mucous gland stroma in a patient with mild asthma. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

5 Fig 4 An overview of some potentially important interactions between mast cells and structural airway cells in the pathogenesis of asthma. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

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