1. Volume 119, Issue 2, Pages 368-376 (August 2000)
Protective role of neurotrophins in experimental inflammation of the rat gut 
Max Reinshagen, Heike Rohm, Martin Steinkamp, Klaus Lieb, Irmlind Geerling, Axel von Herbay, Günther Flämig, Viktor E. Eysselein, Guido Adler 
Gastroenterology 
Volume 119, Issue 2, Pages (August 2000)
DOI: /gast
Copyright © 2000 American Gastroenterological Association Terms and Conditions

2. Fig. 1
Effect of NGF and NT-3 immunoneutralization on (A) macroscopic damage score, (B) microscopic mucosal ulceration, and (C) MPO activity in experimentally induced TNBS colitis at 1 week. *P < 0.05, significantly different from control antibody–treated group. Values are means ± SE; n = 6 rats/group.
Gastroenterology  , DOI: ( /gast )
Copyright © 2000 American Gastroenterological Association Terms and Conditions

3. Fig. 2
Histology of the colon 1 week after induction of TNBS colitis (H&E; B–D). (A) Normal rat colon: intact mucosa without inflammation. (B) Colon of anti-NGF–treated rat shows severe inflammation, characterized by mucosal necrosis (intact mucosa at upper left) and transmural inflammation, which also involves the adjacent pericolic fat tissue, resulting in adhesions with the pancreas (lower left). (C) Colon of control rat: colon with mucosal erosion (intact mucosa at upper right) and with submucosal inflammation; the muscle layer including the myenteric plexus and the serosa are intact. (D) Colon of rat treated with anti–NT-3 shows severe inflammation, characterized by mucosal necrosis and transmural inflammation.
Gastroenterology  , DOI: ( /gast )
Copyright © 2000 American Gastroenterological Association Terms and Conditions

4. Fig. 3
Effects of NGF immunoneutralization and inflammation on immunoreactive (A) CGRP and (B) SP content in colonic homogenates. Values are means ± SE; n = 6 rats/group; CGRP immunoreactivity and SP immunoreactivity are expressed in nmol/mg tissue protein. *P < 0.05, **P < 0.001; significantly different from control.
Gastroenterology  , DOI: ( /gast )
Copyright © 2000 American Gastroenterological Association Terms and Conditions

5. Fig. 4
Effect of NGF immunoneutralization on (A) NGF mRNA expression and (B) Trk A mRNA expression in the DRG (DRG L3-S1) in colons of rats with experimentally induced TNBS colitis at 1 week. Effect of NT-3 immunoneutralization on (C) NT-3 mRNA and (D) Trk C mRNA expression in the colon of rats with TNBS colitis at 1 week.
Gastroenterology  , DOI: ( /gast )
Copyright © 2000 American Gastroenterological Association Terms and Conditions

6. Fig. 5
(A) RT-PCR of colonic CGRP (258 bp) and β-actin (702 bp) in normal rat colon (lane 1); TNBS colitis after 1 week of control IgG antibody treatment (lanes 2–4), TNBS colitis after 1 week of NT-3 antibody treatment (lanes 5–7), and TNBS colitis after 1 week of NGF antibody treatment (lanes 8–10). (B) RT-PCR of colonic β-PPT (120 bp) and β-actin (702 bp) in normal rat colon (lane 1), TNBS colitis after 1 week of control IgG antibody treatment (lanes 2–4), TNBS colitis after 1 week of NT-3 antibody treatment (lanes 5–7), and TNBS colitis after 1 week of NGF antibody treatment (lanes 8–10).
Gastroenterology  , DOI: ( /gast )
Copyright © 2000 American Gastroenterological Association Terms and Conditions