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Concentration of fractional excretion of nitric oxide (FENO): A potential airway biomarker of restored CFTR function  Kavitha Kotha, Rhonda D. Szczesniak,

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Presentation on theme: "Concentration of fractional excretion of nitric oxide (FENO): A potential airway biomarker of restored CFTR function  Kavitha Kotha, Rhonda D. Szczesniak,"— Presentation transcript:

1 Concentration of fractional excretion of nitric oxide (FENO): A potential airway biomarker of restored CFTR function  Kavitha Kotha, Rhonda D. Szczesniak, Anjaparavanda P. Naren, Matthew C. Fenchel, Leo L. Duan, Gary L. McPhail, John P. Clancy  Journal of Cystic Fibrosis  Volume 14, Issue 6, Pages (November 2015) DOI: /j.jcf Copyright © Terms and Conditions

2 Fig. 1 CONSORT flowchart diagram relevant to this study. (A) Cohort 1; (B) Cohort 2. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © Terms and Conditions

3 Fig. 2 Individual changes in (A) FENO, (B) FEV1 % predicted, (C) sweat chloride, and (D) weight in CF patients with gating mutations, before and after one month of ivacaftor therapy. Each curve is from an individual patient, with values to the left before ivacaftor and values to the right after one month of ivacaftor. Genotypes of the five individual subjects were S549N/S549N (CF01-03), S549R/F508del (CF04), and G178R/F508del (CF05). Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © Terms and Conditions

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