1. Size Doesn’t Matter: Shorter Antibody Loops Can Infiltrate HIV’s Env Apex Defenses 
Jinal N. Bhiman, Penny L. Moore 
Immunity 
Volume 46, Issue 5, Pages (May 2017)
DOI: /j.immuni
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
Isolation of the N90-VRC38 V1V2-Directed bNAb Lineage Illustrates a More Attainable Vaccine Target
Left: Virus-like particles (purple) displaying HIV envelope trimers (orange) were used by Cale, Gorman et al. in a unique antigen-specific B cell sorting strategy to isolate the VRC38 bNAb lineage (cyan). Middle: Structural studies showed that, unlike prototypic V1V2 bNAbs (blue), VRC38 bNAbs bound to the V1V2 apex on Env trimers, despite possessing non-protruding loops. The angle of approach of the VRC38 antibodies was off center compared to prototypic V1V2 bNAbs. Right: Antibodies with antigen binding loops of average length, like that of the VRC38 bNAbs, are more frequent in the naive B cell pool than those comparable to prototypic V1V2 bNAbs. Thus, VRC38-like bNAbs may represent a more attainable vaccine HIV target.
Immunity  , DOI: ( /j.immuni )
Copyright © 2017 Elsevier Inc. Terms and Conditions