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Volume 60, Issue 3, Pages (November 2015)

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Presentation on theme: "Volume 60, Issue 3, Pages (November 2015)"— Presentation transcript:

1 Volume 60, Issue 3, Pages 344-345 (November 2015)
Prevent and Cure: RPA Cooperates with Mre11-Sae2 in DNA Secondary Structure Repair  David R.F. Leach  Molecular Cell  Volume 60, Issue 3, Pages (November 2015) DOI: /j.molcel Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 DNA Secondary Structure Formation in Single-Stranded DNA and Formation and Repair of Inversion Duplications (A) DNA secondary structure formation in single-stranded DNA. (i) A DNA palindrome in double-stranded DNA. (ii) A DNA palindrome can form a tight hairpin in single-stranded DNA. (iii) An interrupted palindrome in double-stranded DNA. (iv) An interrupted palindrome can form a hairpin with a loop consisting of the DNA between the inverted sequences. The 3′ ends are represented by half arrowheads, and inverted repeats are represented by complementary red and blue DNA strands. (B) Formation and repair of inversion duplications. (i) Pathway for the formation of inversion duplications. L and R represent the left and right ends of a chromosome. (ii) Zoomed-in panel showing the prevention and repair of a hairpin capped chromosome that is the precursor to an inversion duplication. The 3′ ends are represented by half arrowheads. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2015 Elsevier Inc. Terms and Conditions


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