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Association of Serum Levels of Adipokines and Insulin With Risk of Barrett's Esophagus: A Systematic Review and Meta-Analysis  Apoorva Krishna Chandar,

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Presentation on theme: "Association of Serum Levels of Adipokines and Insulin With Risk of Barrett's Esophagus: A Systematic Review and Meta-Analysis  Apoorva Krishna Chandar,"— Presentation transcript:

1 Association of Serum Levels of Adipokines and Insulin With Risk of Barrett's Esophagus: A Systematic Review and Meta-Analysis  Apoorva Krishna Chandar, Swapna Devanna, Chang Lu, Siddharth Singh, Katarina Greer, Amitabh Chak, Prasad G. Iyer  Clinical Gastroenterology and Hepatology  Volume 13, Issue 13, Pages e4 (December 2015) DOI: /j.cgh Copyright © Terms and Conditions

2 Figure 1 Forest plot showing association between total serum adiponectin and BE risk in comparison with population control subjects (top) and with GERD control subjects (bottom). NSAIDs, nonsteroidal anti-inflammatory drugs; PPI, proton pump inhibitor; SE, standard error. Clinical Gastroenterology and Hepatology  , e4DOI: ( /j.cgh ) Copyright © Terms and Conditions

3 Figure 2 Forest plot showing association between serum leptin and BE risk in comparison with population control subjects (top) and with GERD control subjects (bottom). NSAIDs, nonsteroidal anti-inflammatory drugs; PPI, proton pump inhibitor; SE, standard error. Clinical Gastroenterology and Hepatology  , e4DOI: ( /j.cgh ) Copyright © Terms and Conditions

4 Figure 3 Forest plot showing association between serum insulin and BE risk in comparison with population control subjects (top) and with GERD control subjects (bottom). NSAIDs, nonsteroidal anti-inflammatory drugs; PPI, proton pump inhibitor; SE, standard error. Clinical Gastroenterology and Hepatology  , e4DOI: ( /j.cgh ) Copyright © Terms and Conditions

5 Figure 4 Forest plot showing association between insulin resistance (HOMA-IR) and BE risk in comparison with population control subjects (top) and with GERD control subjects (bottom). SE, standard error. Clinical Gastroenterology and Hepatology  , e4DOI: ( /j.cgh ) Copyright © Terms and Conditions

6 Supplementary Figure 1 Flow diagram summarizing study identification and selection. Clinical Gastroenterology and Hepatology  , e4DOI: ( /j.cgh ) Copyright © Terms and Conditions

7 Supplementary Figure 2 Forest plot showing association between HMW adiponectin and BE risk in comparison with GERD control subjects. Clinical Gastroenterology and Hepatology  , e4DOI: ( /j.cgh ) Copyright © Terms and Conditions

8 Supplementary Figure 3 Forest plot showing association between total serum adiponectin and BE risk when compared with population control subjects in males (top) and females (bottom). NSAIDs, nonsteroidal anti-inflammatory drugs; PPI, proton pump inhibitor; SE, standard error. Clinical Gastroenterology and Hepatology  , e4DOI: ( /j.cgh ) Copyright © Terms and Conditions

9 Supplementary Figure 4 Forest plot showing association between total serum adiponectin and BE risk in comparison with GERD control subjects in males (top) and females (bottom). SE, standard error. Clinical Gastroenterology and Hepatology  , e4DOI: ( /j.cgh ) Copyright © Terms and Conditions

10 Supplementary Figure 5 Forest plot showing association between serum leptin and BE risk in comparison with population control subjects in males (top) and females (bottom). NSAIDs, nonsteroidal anti-inflammatory drugs; PPI, proton pump inhibitor; SE, standard error. Clinical Gastroenterology and Hepatology  , e4DOI: ( /j.cgh ) Copyright © Terms and Conditions

11 Supplementary Figure 6 Forest plot showing sensitivity analysis (Garcia 2014 excluded) for the association between serum leptin and BE risk when compared with population control subjects. NSAIDs, nonsteroidal anti-inflammatory drugs; PPI, proton pump inhibitor; SE, standard error. Clinical Gastroenterology and Hepatology  , e4DOI: ( /j.cgh ) Copyright © Terms and Conditions


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