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Perforated Viscus in a Patient with Non-small Cell Lung Cancer Receiving Bevacizumab  Jhanelle Gray, MD, John Murren, MD, Anupama Sharma, MD, Scott Kelley,

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Presentation on theme: "Perforated Viscus in a Patient with Non-small Cell Lung Cancer Receiving Bevacizumab  Jhanelle Gray, MD, John Murren, MD, Anupama Sharma, MD, Scott Kelley,"— Presentation transcript:

1 Perforated Viscus in a Patient with Non-small Cell Lung Cancer Receiving Bevacizumab 
Jhanelle Gray, MD, John Murren, MD, Anupama Sharma, MD, Scott Kelley, MD, Frank Detterbeck, MD, Gerold Bepler, MD, PhD  Journal of Thoracic Oncology  Volume 2, Issue 6, Pages (June 2007) DOI: /JTO.0b013e31805fea51 Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 (A) and (B) two full thickness (4× magnification) sections of the small bowel mucosa illustrating the tumor involvement extending from the serosa to the overlying mucosa. Notice an absence of tumor necrosis. The perforation in this case is attributed to an overall weakening bowel wall due to the extensive replacement by noncohesive tumor cells. Journal of Thoracic Oncology 2007 2, DOI: ( /JTO.0b013e31805fea51) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Nests of infiltrating neoplastic epithelial cells with pleomorphic features traversing the full thickness of the small bowl wall. Note the relative preservation of the muscularis mucosae (MM) and the overlying small bowl mucosa and villus structures (SBM). Journal of Thoracic Oncology 2007 2, DOI: ( /JTO.0b013e31805fea51) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 High power (40×) view of metastatic undifferentiated carcinoma eroding through the bowel mucosa with associated mucosal ulceration. Journal of Thoracic Oncology 2007 2, DOI: ( /JTO.0b013e31805fea51) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

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