1. Beyond the Transport Function of Import Receptors: What’s All the FUS about? 
Sofya Mikhaleva, Edward A. Lemke 
Cell 
Volume 173, Issue 3, Pages (April 2018)
DOI: /j.cell
Copyright © 2018 Elsevier Inc. Terms and Conditions

2. Figure 1
Multiple Roles of the Nuclear Localization Signal in Cell Function and Disease
A generalized cartoon of the multidomain structure of a typical RNA binding protein (RBP), highlighting LC, RGG, RRM and NLS (PY-NLS in case of FUS) domains. Cation-π interactions can contribute to phase separation as shown for FUS. Upon stress, RBPs can relocate to stress granules (SGs). Amyloid fibers can emerge by assembly of RBPs. Nuclear import receptors (NIRs) employ different approaches to remove proteins from condensates such as SGs, including competition with RNA binding and inhibiting/chaperoning aberrant phase transitions like those implicated in ALS and FTD. Conventionally, NIRs ferry FUS and other RBPs through nuclear pore complexes.
Cell  , DOI: ( /j.cell )
Copyright © 2018 Elsevier Inc. Terms and Conditions