1. Human Skin Keloid Fibroblasts Display Bioenergetics of Cancer Cells
Annette S. Vincent, Than T. Phan, Anandaroop Mukhopadhyay, Hwee Y. Lim, Barry Halliwell, Kim P. Wong 
Journal of Investigative Dermatology 
Volume 128, Issue 3, Pages (March 2008)
DOI: /sj.jid
Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

2. Figure 1
Glucose uptake and lactate accumulation. Glucose and lactate in the culture medium were measured by the glucose oxidase and LDH assays, respectively.
From day 3 to 5 when the cells became confluent, KF consumed significantly more glucose compared with NF, concomitant with a greater production of lactate by KF. *P<0.01 for glucose values; #P<0.05, ##P<0.005 for lactate values.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

3. Figure 2
Rate of glucose utilization in keloid and normal fibroblasts. Tritiated water formed from radiolabeled glucose was separated by Dowex-1-borate column chromatography and measured by liquid scintillation counting. The rate of glucose utilization was significantly higher in KF compared with NF as shown by two representative plots.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

4. Figure 3
Production of ROS and H2O2 in NF and KF. The rates of production of (a) ROS and (b) H2O2 were significantly higher in NF compared with KF. The antioxidants, Trolox and/or ascorbate, at final concentration of 50μM reduced the production of ROS and H2O2. Values are means±SD for n=3; **P<0.01 when compared with basal ROS generation and #P<0.005 for comparison of basal H2O2 production between NF and KF. RFU, relative fluorescence unit.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

5. Figure 4
An overview of glycolysis and OXPHOS showing sites of action of respiratory substrates and inhibitors (in parentheses) used in this study.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions