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Association Between Pharmacokinetics of Adalimumab and Mucosal Healing in Patients With Inflammatory Bowel Diseases  Xavier Roblin, Hubert Marotte, Melanie.

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Presentation on theme: "Association Between Pharmacokinetics of Adalimumab and Mucosal Healing in Patients With Inflammatory Bowel Diseases  Xavier Roblin, Hubert Marotte, Melanie."— Presentation transcript:

1 Association Between Pharmacokinetics of Adalimumab and Mucosal Healing in Patients With Inflammatory Bowel Diseases  Xavier Roblin, Hubert Marotte, Melanie Rinaudo, Emilie Del Tedesco, Amelie Moreau, Jean Marc Phelip, Christian Genin, Laurent Peyrin–Biroulet, Stephane Paul  Clinical Gastroenterology and Hepatology  Volume 12, Issue 1, Pages e2 (January 2014) DOI: /j.cgh Copyright © 2014 AGA Institute Terms and Conditions

2 Figure 1 (A) Comparison of ADA trough levels between IBD patients with MH and those without MH (P < .005). (B) Quartiles of ADA trough levels for the obtention of MH (P = .001). Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2014 AGA Institute Terms and Conditions

3 Figure 2 Comparison of ADA trough levels between IBD patients with MH and those without MH in CD and UC (P = .04). Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2014 AGA Institute Terms and Conditions

4 Figure 3 ROC curves for trough levels of ADA in IBD patients (MH vs no MH). NPV, negative predictive value; PPV, positive predictive value. Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2014 AGA Institute Terms and Conditions

5 Supplementary Figure 1 (A) Comparison of ADA trough levels between IBD patients in clinical remission (CR) and those with active disease (P = .012). (B) Quartiles of ADA values for the obtention of clinical remission (P = .001). Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2014 AGA Institute Terms and Conditions

6 Supplementary Figure 2 ROC curves for trough levels of ADA in IBD patients (CR vs no CR). CR, clinical remission; NPV, negative predictive value; PPV, positive predictive value. Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2014 AGA Institute Terms and Conditions


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