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Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis  Richard D. Kenagy, PhD, Nozomi Fukai,

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Presentation on theme: "Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis  Richard D. Kenagy, PhD, Nozomi Fukai,"— Presentation transcript:

1 Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis  Richard D. Kenagy, PhD, Nozomi Fukai, MD, PhD, Seung-Kee Min, MD, Florencia Jalikis, MD, Ted R. Kohler, MD, Alexander W. Clowes, MD  Journal of Vascular Surgery  Volume 49, Issue 5, Pages (May 2009) DOI: /j.jvs Copyright © 2009 Society for Vascular Surgery Terms and Conditions

2 Fig 1 DNA synthesis in reponse to growth factors by saphenous vein smooth muscle cells (A) and fibroblasts (B) from veins that developed stenosis (open bars) compared with veins that remained patent (closed bars). Values are the mean ± SEM of fold of control values of 3H-thymidine incorporation after treatment with the indicated growth factors. Values for N are indicated within the bars. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2009 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Effect of heparin (100 μg/ml) on PDGF-BB- mediated 3H-thymidine incorporation (A; *P < .05 comparing PDGF-BB plus heparin vs. PDGF-BB alone) and on thrombin-mediated 3H-thymidine incorporation (B; *P < .05 comparing thrombin plus heparin vs. thrombin alone). SMC: smooth muscle cells; Fibs: fibroblasts; values for N are indicated in the bars. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2009 Society for Vascular Surgery Terms and Conditions

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