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Lengthy suppression of vascular proliferation by a chymase inhibitor in dog grafted veins  Koutaro Tsunemi, MDa,b, Shinji Takai, PhDa, Masayoshi Nishimoto,

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Presentation on theme: "Lengthy suppression of vascular proliferation by a chymase inhibitor in dog grafted veins  Koutaro Tsunemi, MDa,b, Shinji Takai, PhDa, Masayoshi Nishimoto,"— Presentation transcript:

1 Lengthy suppression of vascular proliferation by a chymase inhibitor in dog grafted veins 
Koutaro Tsunemi, MDa,b, Shinji Takai, PhDa, Masayoshi Nishimoto, MDa,b, Atsushi Yuda, MDa,b, Denan Jin, MDa, Masato Sakaguchi, PhDa, Yoshihide Sawada, MDb, Kunio Asada, MDb, Keiichiro Kondo, MDb, Shinjiro Sasaki, MDb, Mizuo Miyazaki, MDa  The Journal of Thoracic and Cardiovascular Surgery  Volume 124, Issue 3, Pages (September 2002) DOI: /mtc Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

2 Fig. 1 ACE and chymase activities in control veins, placebo-treated veins, and chymase inhibitor-treated veins. Each bar represents mean value ± SEM (n = 4). *P <.05 versus placebo-treated group. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

3 Fig. 2 Total angiotensin II-forming activity in control veins, placebo-treated veins, and chymase inhibitor-treated veins. Each bar represents mean value ± SEM (n = 4). *P <.05 versus placebo-treated group. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

4 Fig. 3 Typical histologic cross-sections of the grafted veins treated with placebo (left) and chymase inhibitor (right) stained with elastica-van Gieson stain. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

5 Fig. 4 The intimal area and ratio of intimal area to medial area in control veins, placebo-treated veins, and chymase inhibitor-treated veins. Each bar represents mean value ± SEM (n = 4). *P <.05 versus placebo-treated group. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

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