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Early effects of right ventricular volume overload on ventricular performance and β- adrenergic signaling  Ashish S. Shah, MD, B.Zane Atkins, MD, Jonathan.

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Presentation on theme: "Early effects of right ventricular volume overload on ventricular performance and β- adrenergic signaling  Ashish S. Shah, MD, B.Zane Atkins, MD, Jonathan."— Presentation transcript:

1 Early effects of right ventricular volume overload on ventricular performance and β- adrenergic signaling  Ashish S. Shah, MD, B.Zane Atkins, MD, Jonathan A. Hata, BA, Oliver Tai, BS, Alan P. Kypson, MD, R.Eric Lilly, MD, Walter J. Koch, PhD, Donald D. Glower, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 120, Issue 2, Pages (August 2000) DOI: /mtc Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

2 Fig. 1 Schematic representation of sonomicrometric crystal positions and axes used for modeling of the RV. a, Base-apex major axis; A, anterior minor axis; P, posterior minor axis represented as b in the model; c, LV free wall septum; d, RV free wall septum. Vena caval occluders and a silicone rubber pleural catheter is also shown. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

3 Fig. 2 Representative pressure-volume loops at baseline and either acutely or after 1 week of TR for a single animal. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

4 Fig. 3 RV chamber performance was assessed by using the SW-EDVc. RV volume overload resulted in a sustained depression of RV chamber performance. *P =.03 versus baseline. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

5 Fig. 4 Total β-AR density (mean ± SEM) in animals with TR at 1 week (n = 9) versus control animals (n = 8). No statistically significant difference was observed between each group and chamber (P =.5). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

6 Fig. 5 Summary of GRK activity (mean ± SEM). A 2-fold elevation of GRK activity was seen in TR animals over control animals. Inset, A representative GRK rhodopsin phosphorylation assay from 3 animals with 1 week of TR compared with a sham-operated control animal and a positive control animal (arrow) for both the left and right ventricle of the respective dog. *P <.02 versus respective control animals. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

7 Fig. 6 Specific protein immunoblotting reveals significant elevations of βARK1 myocardial protein content in animals with TR compared with sham-operated control animals (mean ± SEM). *P <.02 versus respective control animals. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

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