1. Volume 16, Issue 10, Pages 1109-1121 (October 2009)
Biosynthesis of Macrolactam BE Involves Two Distinct PKS Systems and Amino Acid Processing Enzymes for Generation of the Aminoacyl Starter Unit 
Hanne Jørgensen, Kristin F. Degnes, Håvard Sletta, Espen Fjærvik, Alexander Dikiy, Lars Herfindal, Per Bruheim, Geir Klinkenberg, Harald Bredholt, Gyrid Nygård, Stein O. Døskeland, Trond E. Ellingsen, Sergey B. Zotchev 
Chemistry & Biology 
Volume 16, Issue 10, Pages (October 2009)
DOI: /j.chembiol
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2. Figure 1 Structures of BE-14106 and Similar Small-Ring Macrolactams
Chemistry & Biology  , DOI: ( /j.chembiol )
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3. Figure 2
Organization of the BE Biosynthetic Gene Cluster in Streptomyces sp. DSM 21069
PKS, green; genes presumed to be involved in modification of aminoacyl starter, red; regulators/efflux pump, blue; post-PKS modification, yellow; not involved in biosynthesis of BE-14106, gray. Coverage of the four sequenced cosmids is shown.
Chemistry & Biology  , DOI: ( /j.chembiol )
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4. Figure 3
Incorporation of Nitrogen and Carbon Atoms from Unlabeled Glycine into the BE Molecule in the Feeding Experiments
Experiments were performed using the Silantes growth media supplemented with ammonium sulfate (A) or sodium nitrate (B).
Chemistry & Biology  , DOI: ( /j.chembiol )
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5. Figure 4 Proposed Model for the Biosynthesis of BE-14106
(A) Synthesis and activation of the acyl amino acid starter.
(B) Extension of the aminoacyl starter, cyclization, and C-8 hydroxylation. Malonyl-CoA-specific AT domains are shown in orange and methylmalonyl-CoA-specific AT domains are shown in blue.
Chemistry & Biology  , DOI: ( /j.chembiol )
Copyright © 2009 Elsevier Ltd Terms and Conditions