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Disease-specific remodeling of cardiac mitochondria after a left ventricular assist device  Paul M Heerdt, MD, PhD, Michael Schlame, MD, Roswitha Jehle,

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Presentation on theme: "Disease-specific remodeling of cardiac mitochondria after a left ventricular assist device  Paul M Heerdt, MD, PhD, Michael Schlame, MD, Roswitha Jehle,"— Presentation transcript:

1 Disease-specific remodeling of cardiac mitochondria after a left ventricular assist device 
Paul M Heerdt, MD, PhD, Michael Schlame, MD, Roswitha Jehle, MD, Alessandro Barbone, MD, Daniel Burkhoff, MD, PhD, Thomas J.J Blanck, MD, PhD  The Annals of Thoracic Surgery  Volume 73, Issue 4, Pages (April 2002) DOI: /S (01)

2 Fig 1 Representative chromatogram for cardiolipin molecular species.( L4 = tetralinoleoyl-cardiolipin; L3O = trilinoleoyl-oleoyl-cardiolipin; L2O2 = dilinoleoyl-dioleoyl-cardiolipin.) The Annals of Thoracic Surgery  , DOI: ( /S (01) )

3 Fig 2 Total cardiolipin content and myocyte diameter in four nonfailing, nine failing (CHF), and 12 left ventricular assist device (LVAD)-supported hearts. ∗Difference from nonfailing. Data are presented as mean ± standard error. The Annals of Thoracic Surgery  , DOI: ( /S (01) )

4 Fig 3 Ratios of cardiolipin molecular species with all heart samples pooled or divided by underlying disease. Data are presented as mean ± standard error. (CHF = failing hearts; DCM = dilated cardiomyopathy; ICM = ischemic cardiomyopathy; LVAD = left ventricular assist device-supported hearts; L4 = tetralinoleoyl-cardiolipin; L3O = trilinoleoyl-oleoyl-cardiolipin; L2O2 = dilinoleoyl-dioleoyl-cardiolipin. ∗Difference from nonfailing; diamond = difference between CHF versus LVAD.) The Annals of Thoracic Surgery  , DOI: ( /S (01) )

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