1. Translocation Mapping Exposes the Risky Lifestyle of B Cells
Rachel Patton McCord, Job Dekker 
Cell 
Volume 147, Issue 1, Pages (September 2011)
DOI: /j.cell
Copyright © 2011 Elsevier Inc. Terms and Conditions

2. Figure 1
Factors Predisposing Loci to Double-Strand Breaks and Translocations
Genome-wide translocation mapping identifies translocations that form when a DNA double-strand break (DSB) is artificially introduced in a defined location by the I-SceI meganuclease (center). The majority of induced DSBs are repaired locally, but many form translocation junctions with endogenous DSBs. These endogenous DSBs, often mediated by AID activity, occur at transcription start sites (left), class switch recombination sites (top), and elsewhere throughout the genome (right).
Cell  , 20-22DOI: ( /j.cell )
Copyright © 2011 Elsevier Inc. Terms and Conditions