1. Volume 125, Issue 4, Pages 1094-1104 (October 2003)
Low microvessel density is an unfavorable histoprognostic factor in pancreatic endocrine tumors 
Anne-Marie Marion-Audibert, Cécile Barel, Géraldine Gouysse, Jérôme Dumortier, Frank Pilleul, Céline Pourreyron, Valérie Hervieu, Gilles Poncet, Catherine Lombard-Bohas, Jean-Alain Chayvialle, Christian Partensky, Jean-Yves Scoazec 
Gastroenterology 
Volume 125, Issue 4, Pages (October 2003)
DOI: /S (03)

2. Figure 1
Immunohistochemical results. Two examples of CD34 immunostaining of endocrine pancreatic tumors are shown in A and B; in A, intratumoral microvascular density is high: CD34+ structures are numerous and small; in B, intratumoral microvascular density is low: CD34+ structures are rare and large. In normal Langerhans’ islets (arrow), capillary vessels are characterized by a faint and heterogeneous expression of CD34 (C) and of the smooth muscle isoform of α actin (D). In contrast, the smooth muscle isoform of α actin is strongly detectable along intratumoral capillary vessels and in the wall of arterioles (arrow) (E). (Immunoperoxidase followed by nuclear staining with Mayer’s hematoxylin; original magnifications: A, 200×; B, 200×; C, 350×; D, 350×; E, 200×).
Gastroenterology  , DOI: ( /S (03) )

3. Figure 2
Correlation between intratumoral microvascular density and tumor size.
Gastroenterology  , DOI: ( /S (03) )

4. Figure 3
Intratumoral microvascular density (MVD) (mean ± SD) in pancreatic endocrine tumors according to the hormonal status.
Gastroenterology  , DOI: ( /S (03) )

5. Figure 4
Survival curves (according to Kaplan-Meier) for all the patients of the study group according to intratumoral microvascular density < 30 (open circles) or > 30 (open squares); P < 0.05 (log-rank test).
Gastroenterology  , DOI: ( /S (03) )