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Bone structural changes in osteoarthritis as a result of mechanoregulated bone adaptation: a modeling approach  L.G.E. Cox, B. van Rietbergen, C.C. van.

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Presentation on theme: "Bone structural changes in osteoarthritis as a result of mechanoregulated bone adaptation: a modeling approach  L.G.E. Cox, B. van Rietbergen, C.C. van."— Presentation transcript:

1 Bone structural changes in osteoarthritis as a result of mechanoregulated bone adaptation: a modeling approach  L.G.E. Cox, B. van Rietbergen, C.C. van Donkelaar, K. Ito  Osteoarthritis and Cartilage  Volume 19, Issue 6, Pages (June 2011) DOI: /j.joca Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

2 Fig. 1 The different loading conditions: (a) normal, (b) obesity, strenuous exercise, (c) malalignment, ACL injury, partial meniscectomy. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

3 Fig. 2 Simulated bone structures for different conditions: (a) normal, (b) obesity, strenuous exercise, (c) ACL injury, partial meniscectomy, malalignment, (d) reduced mineralization, (e) osteopetrosis. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

4 Fig. 3 Average SED in the bone during remodeling after changing the model parameters to simulate conditions associated with OA. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

5 Fig. 4 Apparent bone stiffness prior to and after the onset of different conditions, and after remodeling. Model parameters. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions


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