1. Comparison of the LL95%CI rule to a PE threshold for maximal RB classification: sensitivity and specificity for the MCBS LL95%CI ≤0.65 rule versus the ROC curve for PE rules ranging from 0.60 to 0.90 (time-to-event median control=6 months). (A–C) Power 80%.
Comparison of the LL95%CI rule to a PE threshold for maximal RB classification: sensitivity and specificity for the MCBS LL95%CI ≤0.65 rule versus the ROC curve for PE rules ranging from 0.60 to 0.90 (time-to-event median control=6 months). (A–C) Power 80%. (D–F) Power 90%. Annotation: Left and centre panels: true HR ≤0.65 and HR≤0.70, are respectively classified as big benefit, contrasted to a small benefit classification of true HR>0.80. Right panels: true HR ≤0.75 is classified as a relatively big benefit, contrasted to a small benefit classification of true HR>0.75. Red star: the MCBS LL95%CI≤0.65 rule for HR. ROC curve (black): PE rules ranging from 0.60 to 0.90.
Urania Dafni et al. ESMO Open 2017;2:e000216
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