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Genome-wide copy number variation analysis in monozygotic twins
Xiling Liu, Zhenmin Zhao, Qiannan Xu, Zheng Wang, Yingnan Bian, Suhua Zhang, Chengtao Li Forensic Science International: Genetics Supplement Series Volume 6, Pages e218-e220 (December 2017) DOI: /j.fsigss Copyright © 2017 Elsevier B.V. Terms and Conditions
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Fig. 1 CN discordance between MZ twins. (A) A chromosomal karyogram depicting loci with CN discordance between MZ twins (Black bars are all detected CNVs; red bars are CNVs in non-coding regions). (B) Overlap between CNV loci in pairs of MZ twins. (C) Overlap between non-coding CNV loci in pairs of MZ twins. (D) Proportions of CNVs located in promoters (blue), UTRs (green), exons (orange), introns (purple), and intergenic regions (brown). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) Forensic Science International: Genetics Supplement Series 2017 6, e218-e220DOI: ( /j.fsigss ) Copyright © 2017 Elsevier B.V. Terms and Conditions
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Fig. 2 Difference in DNA methylation between MZ twins in non-coding regions showing CN discordance between MZ twins (redbar), all detected regions showing CN discordance between MZ twins (orangebar), and regions showing CN concordance between MZ twins (graybar). The symbols above the bars show the significance of comparison of DNA methylation change between MZ twins in different groups based on a one-sided Wilcoxon test (***: P<0.001; *: P<0.05). Forensic Science International: Genetics Supplement Series 2017 6, e218-e220DOI: ( /j.fsigss ) Copyright © 2017 Elsevier B.V. Terms and Conditions
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