Presentation is loading. Please wait.

Presentation is loading. Please wait.

Novel baseline predictors of adverse events during oral immunotherapy in children with peanut allergy  Yamini V. Virkud, MD, MA, MPH, A. Wesley Burks,

Published byErling Birkeland Modified over 5 years ago

Similar presentations

Presentation on theme: "Novel baseline predictors of adverse events during oral immunotherapy in children with peanut allergy  Yamini V. Virkud, MD, MA, MPH, A. Wesley Burks,"— Presentation transcript:

1 Novel baseline predictors of adverse events during oral immunotherapy in children with peanut allergy  Yamini V. Virkud, MD, MA, MPH, A. Wesley Burks, MD, Pamela H. Steele, CPNP, Lloyd J. Edwards, PhD, Jelena P. Berglund, PhD, Stacie M. Jones, MD, Amy M. Scurlock, MD, Tamara T. Perry, MD, Robert D. Pesek, MD, Brian P. Vickery, MD  Journal of Allergy and Clinical Immunology  Volume 139, Issue 3, Pages e5 (March 2017) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Consort diagram of the study population.
Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Frequencies of AEs, by symptoms reported, over the buildup and maintenance phases of OIT. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Distributions of AEs, by month and by AR status. P < .001.
Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Frequencies of AEs resulting in epinephrine use. Patterns of use of epinephrine concurrently with administration of antihistamines, albuterol, oral corticosteroids, or an ED visit (A), and in response to specific symptoms (cough, wheeze, hives, abdominal [Abd] pain, or vomiting) (B). Overlap of AEs with 2 or more given symptoms (ex: cough and wheeze) may be present. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E1 Histogram of rates and counts of AEs. Subjects A, B, and C experienced the top 3 highest counts of AEs, while subjects C, D, and E experienced the top 3 highest rates of AEs. Modeling the number of AEs based on the total count (left) captures the elevated amount of AEs experienced by individuals A, B, and C. Evaluating total counts, however, misses individuals D and E, who experienced low numbers of AEs over a short period of time, leading to early dropout. By adjusting for the time on therapy, modeling the rate of AEs (right) appropriately captures the experience of those individuals, like D and E, whose symptoms led them to discontinue OIT. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Novel baseline predictors of adverse events during oral immunotherapy in children with peanut allergy  Yamini V. Virkud, MD, MA, MPH, A. Wesley Burks,"

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,
Characteristics of childhood peanut allergy in the Australian Capital Territory, 1995 to 2007 Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Keith B.G.

Characteristics of childhood peanut allergy in the Australian Capital Territory, 1995 to 2007 Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Keith B.G.
Allergen immunotherapy: A practice parameter third update

Allergen immunotherapy: A practice parameter third update
Corinne A. Keet, MD, MS, Pamela A

Corinne A. Keet, MD, MS, Pamela A
A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy  Satya D. Narisety,

A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy  Satya D. Narisety,
Risk of an asthma exacerbation after bariatric surgery in adults

Risk of an asthma exacerbation after bariatric surgery in adults
Sublingual immunotherapy for peanut allergy: A randomized, double-blind, placebo- controlled multicenter trial  David M. Fleischer, MD, A. Wesley Burks,

Sublingual immunotherapy for peanut allergy: A randomized, double-blind, placebo- controlled multicenter trial  David M. Fleischer, MD, A. Wesley Burks,
Fatty acids, inflammation, and asthma

Fatty acids, inflammation, and asthma
Alison M. Hofmann, MD, Amy M. Scurlock, MD, Stacie M

Alison M. Hofmann, MD, Amy M. Scurlock, MD, Stacie M
Advances in food allergy in 2015

Advances in food allergy in 2015
Stacie M. Jones, MD, Scott H. Sicherer, MD, A

Stacie M. Jones, MD, Scott H. Sicherer, MD, A
Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood  Zaraquiza Zolkipli, MSc,

Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood  Zaraquiza Zolkipli, MSc,
Caregivers report a wide variety of early signs and symptoms of impending asthma exacerbations that are not different between preschool and school-aged.

Caregivers report a wide variety of early signs and symptoms of impending asthma exacerbations that are not different between preschool and school-aged.
Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study  John M. Brehm, MD, MPH, Brooke Schuemann, BS,

Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study  John M. Brehm, MD, MPH, Brooke Schuemann, BS,
Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD 

Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD 
Is 9 more than 2 also in allergic airway inflammation?

Is 9 more than 2 also in allergic airway inflammation?
Children with allergic and nonallergic rhinitis have a similar risk of asthma  Bo Lund Krogsgaard Chawes, MD, Klaus Bønnelykke, MD, PhD, Eskil Kreiner-Møller,

Children with allergic and nonallergic rhinitis have a similar risk of asthma  Bo Lund Krogsgaard Chawes, MD, Klaus Bønnelykke, MD, PhD, Eskil Kreiner-Møller,
Fatty acids, inflammation, and asthma

Fatty acids, inflammation, and asthma
Joe K. Gerald, MD, PhD, Roni Grad, MD, William C. Bailey, MD, Lynn B

Joe K. Gerald, MD, PhD, Roni Grad, MD, William C. Bailey, MD, Lynn B
Food allergy: A practice parameter update—2014

Food allergy: A practice parameter update—2014

Similar presentations

Ads by Google