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Arginine-vasopressin attenuates beneficial norepinephrine effect on jejunal mucosal tissue oxygenation during endotoxinaemia  S. Maier, W. Hasibeder,

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Presentation on theme: "Arginine-vasopressin attenuates beneficial norepinephrine effect on jejunal mucosal tissue oxygenation during endotoxinaemia  S. Maier, W. Hasibeder,"— Presentation transcript:

1 Arginine-vasopressin attenuates beneficial norepinephrine effect on jejunal mucosal tissue oxygenation during endotoxinaemia  S. Maier, W. Hasibeder, W. Pajk, C. Hengl, H. Ulmer, H. Hausdorfer, B. Wurzinger, H. Knotzer  British Journal of Anaesthesia  Volume 103, Issue 5, Pages (November 2009) DOI: /bja/aep239 Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Experimental protocol. After baseline measurements at time point 0 min (BL), a bolus injection of 200 µg of E. coli LPS followed by a continuous infusion of 0.1 µg kg−1 min−1 throughout the experiment was administered. After another measurement in endotoxinaemia at time point 30 min (BLLPS), continuous infusion of increasing dosages of NE (NE group), NE plus a constant dosage of arginine vasopressin (AVP; NE/AVP group), or saline (CON group) was started. Further measurements were made in 20 min intervals (M1–M5). British Journal of Anaesthesia  , DOI: ( /bja/aep239) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Systemic haemodynamic and oxygen transport variables. *Significant vs baseline. #Significant vs control. British Journal of Anaesthesia  , DOI: ( /bja/aep239) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

4 Fig 3 Arterial and intestinal venous lactate, intestinal oxygen extraction ratio, and mesenteric artery blood flow. *Significant vs baseline. #Significant vs control. British Journal of Anaesthesia  , DOI: ( /bja/aep239) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

5 Fig 4 Jejunal microcirculatory parameters. *Significant vs baseline. #Significant vs control. §Significant between combination of NE/vasopressin and NE alone. British Journal of Anaesthesia  , DOI: ( /bja/aep239) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions


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