1. MOSPD2 tethers the ER to organelles bearing FFAT‐containing proteins
MOSPD2 tethers the ER to organelles bearing FFAT‐containing proteins Schematic representation of ER–endosome, ER–mitochondria, and ER–Golgi contacts involving MOSPD2 and a number of its interacting partners: STARD3NL, STARD3, ORP1L, PTPIP51, and STARD11. LE, late endosome; ER, endoplasmic reticulum; TM, transmembrane domain; MSP, Major Sperm Protein domain; FFAT, Two phenylalanines in an acidic tract motif [9], [26]; CRAL‐TRIO, cellular retinaldehyde‐binding protein and triple functional domain protein domain [48]; MENTAL, metastatic lymph node 64 N‐terminal domain, anchoring STARD3 and STARD3NL to the LE membrane [53], [65]; START, steroidogenic acute regulatory protein (StAR)‐related lipid Transfer domain; in STARD11 (CERT), the START domain is mediating ceramide transfer from the ER to the Golgi [70], and in STARD3, the START domain is involved in cholesterol transfer from the ER to LE (STARD3) [23]; PH, pleckstrin homology domain; this domain mediates the association of STARD11 with the Golgi membrane by interacting with PI(4)P; in ORP1L, it might also be involved in phosphoinositide binding‐mediated membrane interaction [51], [71]; ORD, oxysterol‐binding protein (OSBP)‐related domain [72]; AR, ankyrin repeat domain involved in the interaction with Rab7 at the LE membrane [51]; CC, coiled‐coil.
Thomas Di Mattia et al. EMBO Rep. 2018;19:e45453
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