1. Proportional effects on cause-specific mortality per 1-mmol/L LDL-cholesterol reduction
Cause of death
Treatment-arm events, % (n=45 054)
Control-arm events, % (n=45 002)
Relative risk
(95% CI)
All-cause
8.5
9.7
0.88 ( )
Coronary heart disease
3.4
4.4
0.81 ( )
Any non-coronary-heart-disease
1.2
1.3
0.93 ( )
Stroke
0.6
0.91 ( )
Other vascular
0.7
0.95 ( )
Any vascular
4.7
5.7
0.83 ( )
Any nonvascular
3.8
4.0
0.95 ( )
Cancer
2.4
1.01 ( )
Cholesterol Treatment Trialists' (CTT) Collaborators. Lancet 2005; available at:

2. Proportional effects on major vascular events per 1-mmol/L LDL-cholesterol reduction
End point
Treatment-arm events, %
(n=45 054)
Control-arm events, % (n=45 002
Relative risk
(95% CI)
Any major vascular event
14.1
17.8
0.79 ( )
Any major coronary event
7.4
9.8
0.77 ( )
Nonfatal MI
4.4
6.2
0.74 ( )
CHD death
3.4
0.81 ( )
Any coronary revascularization
5.8
7.6
0.76 ( )
CABG
1.6
2.2
0.75 ( )
PTCA
1.1
1.5
0.79 ( )
Unspecified
3.1
3.9
0.76 ( )
Any stroke
3.0
3.7
0.83 ( )
Cholesterol Treatment Trialists' (CTT) Collaborators. Lancet 2005; available at: