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John Blebea, MD, Robert A. Cambria, MD, David DeFouw, PhD, Richard N

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Presentation on theme: "John Blebea, MD, Robert A. Cambria, MD, David DeFouw, PhD, Richard N"— Presentation transcript:

1 Iloprost attenuates the increased permeability in skeletal muscle after ischemia and reperfusion 
John Blebea, MD, Robert A. Cambria, MD, David DeFouw, PhD, Richard N. Feinberg, PhD, Robert W. Hobson, MD, Walter N. Duran, PhD  Journal of Vascular Surgery  Volume 12, Issue 6, Pages (December 1990) DOI: /mva Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 1 A, Control cremaster muscle. Light microscopy of nonischemic muscle in cross-section demonstrates normal myofibrils (M) and even spacing between them (boxes). (Toluidine blue dye; original magnification ×250.) B, Ischemic cremaster muscle. After 2 hours of ischemia and reperfusion, increased interstitial edema (boxes) is evident between the muscle fibers (M). (Toluidine blue dye; original magnification ×250.) Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 2 A, Normal capillary. Electron micrograph of a capillary endothelial cell in a control cremaster muscle. The architecture of the cell is normal in appearance, without swelling, and with a smooth luminal surface surrounding the red blood cell (rbc) occupying the capillary. (Original magnification × 14,500.) B, Ischemic capillary. After ischemia blistering occurs (cytoplasmic vacuolization) visible within the capillary endothelial cell (arrows) and an rbc in its lumen. (Original magnification × 14,500.) C, Ischemic capillary. Nuclear swelling (N) and visualization of an endothelial cell gap junction (arrows) is evident after ischemia and reperfusion. (Original magnification × 14,500.) D, Ischemic cremaster muscle. An intravascular leukocyte (L) is present within the vessel after ischemia and reperfusion. Normal myofibrils (M) are seen in association with intermyofibrillar edema (curved arrows). (Original magnification × 14,500.) Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

4 Fig. 3 Macromolecular clearances after 2 hours of ischemia and reperfusion in both control and iloprost-treated animals. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

5 Fig. 4 Cumulative macromolecular clearance as a function of time in the two groups of animals. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions


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