Presentation is loading. Please wait.

Presentation is loading. Please wait.

Kerstin Bauermeister, MSc, Barbara K

Published byAndreas Schäfer Modified over 5 years ago

Similar presentations

Presentation on theme: "Kerstin Bauermeister, MSc, Barbara K"— Presentation transcript:

1 Assessment of component-resolved in vitro diagnosis of celeriac allergy 
Kerstin Bauermeister, MSc, Barbara K. Ballmer-Weber, MD, Merima Bublin, PhD, Philipp Fritsche, MD, Kay-Martin O. Hanschmann, MSc, Karin Hoffmann-Sommergruber, PhD, Jonas Lidholm, PhD, Christina Oberhuber, PhD, Stefanie Randow, Thomas Holzhauser, PhD, Stefan Vieths, PhD  Journal of Allergy and Clinical Immunology  Volume 124, Issue 6, Pages e2 (December 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A, Prevalence of sensitization to different extracts and single allergens, as determined by ImmunoCAP analysis for patients with celeriac allergy (gray bars, n = 24) and control subjects with birch pollen allergy (black bars; n = 20). B, Concentration of specific IgE antibodies to tested allergens among patients with celeriac allergy (n = 24) and celeriac-tolerant atopic control subjects (n = 20). The dotted line indicates the 0.35 kUA/L cutoff point. Median values of 0.35-kUA/L or greater are indicated by horizontal bars. Numbers of negative results for each test are indicated below the cutoff line. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Dose-dependent mediator release of RBL cells sensitized with sera of 10 patients with celeriac allergy. Serum from a nonallergic subject was applied as a negative control. Plots contain response curves obtained after stimulation with rBet v 1 (A), rApi g 1 (B), and nApi g 5 (C). Mediator release is expressed as a percentage of total β-hexosaminidase content determined after cell lysis. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Correlation between reactivity to celeriac extract and specific reactivity to celeriac allergen components (sum of specific IgE values of all single celeriac allergens), as determined by means of ImmunoCAP analysis (R2 = 0.59). Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Correlation between Api g 5–specific IgE levels and IgE levels to CCDs (MUXF3 glycan of bromelain) for patients with celeriac allergy, as determined by means of ImmunoCAP analysis. IgE reactivity to nApi g 5 is slightly higher than to CCDs. The calculation of the correlation coefficient (R2 = 0.90) included all subjects with detectable specific IgE levels. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Kerstin Bauermeister, MSc, Barbara K"

Similar presentations

Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity  Abena S. Amoah, MSc, Benedicta.

Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity  Abena S. Amoah, MSc, Benedicta.
Detection of novel occupational wood allergens in locust wood dust (Robinia pseudoacacia L.)  Sabine Kespohl, PhD, Rolf Merget, MD, Axel Overlack, MD,

Detection of novel occupational wood allergens in locust wood dust (Robinia pseudoacacia L.)  Sabine Kespohl, PhD, Rolf Merget, MD, Axel Overlack, MD,
Biologic allergen assay for in vivo test allergens with an in vitro model of the murine type I reaction  Andreas Hoffmann, VMD, Stefan Vieths, PhD, Dieter.

Biologic allergen assay for in vivo test allergens with an in vitro model of the murine type I reaction  Andreas Hoffmann, VMD, Stefan Vieths, PhD, Dieter.
Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever  Laura Hatzler, Valentina Panetta,

Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever  Laura Hatzler, Valentina Panetta,
Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study  Anna.

Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study  Anna.
The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy  Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy  Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.
Birch pollen–related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies  Marija Geroldinger-Simic, MD, Thomas Zelniker,

Birch pollen–related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies  Marija Geroldinger-Simic, MD, Thomas Zelniker,
Cor a 1–reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen–associated food allergy to hazelnut  Claudia.

Cor a 1–reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen–associated food allergy to hazelnut  Claudia.
Kuan-Wei Chen, PhD, Katharina Blatt, MSc, Wayne R

Kuan-Wei Chen, PhD, Katharina Blatt, MSc, Wayne R
High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE  Elizabeth A. Erwin,

High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE  Elizabeth A. Erwin,
Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 
Role of the basophil activation test in the diagnosis of local allergic rhinitis  Enrique Gómez, PhD, Paloma Campo, MD, PhD, Carmen Rondón, MD, PhD, Esther.

Role of the basophil activation test in the diagnosis of local allergic rhinitis  Enrique Gómez, PhD, Paloma Campo, MD, PhD, Carmen Rondón, MD, PhD, Esther.
Giant ragweed specific immunotherapy is not effective in a proportion of patients sensitized to short ragweed: Analysis of the allergenic differences.

Giant ragweed specific immunotherapy is not effective in a proportion of patients sensitized to short ragweed: Analysis of the allergenic differences.
Cor a 1–reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen–associated food allergy to hazelnut  Claudia.

Cor a 1–reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen–associated food allergy to hazelnut  Claudia.
IgE cross-reactivity between the major peanut allergen Ara h 2 and the nonhomologous allergens Ara h 1 and Ara h 3  Merima Bublin, PhD, Maria Kostadinova,

IgE cross-reactivity between the major peanut allergen Ara h 2 and the nonhomologous allergens Ara h 1 and Ara h 3  Merima Bublin, PhD, Maria Kostadinova,
Skin test diagnosis of grass pollen allergy with a recombinant hybrid molecule  Carine Metz-Favre, MD, Birgit Linhart, PhD, Margarete Focke-Tejkl, PhD,

Skin test diagnosis of grass pollen allergy with a recombinant hybrid molecule  Carine Metz-Favre, MD, Birgit Linhart, PhD, Margarete Focke-Tejkl, PhD,
Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy  Julie Wang, MD,

Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy  Julie Wang, MD,
Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD 

Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD 
Malassezia sympodialis thioredoxin–specific T cells are highly cross-reactive to human thioredoxin in atopic dermatitis  Hari Balaji, MSc, Annice Heratizadeh,

Malassezia sympodialis thioredoxin–specific T cells are highly cross-reactive to human thioredoxin in atopic dermatitis  Hari Balaji, MSc, Annice Heratizadeh,
Birch pollen immunotherapy results in long-term loss of Bet v 1–specific TH2 responses, transient TR1 activation, and synthesis of IgE-blocking antibodies 

Birch pollen immunotherapy results in long-term loss of Bet v 1–specific TH2 responses, transient TR1 activation, and synthesis of IgE-blocking antibodies 

Similar presentations

Ads by Google