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P-selectin participates in cardiopulmonary bypass–induced inflammatory response in association with nitric oxide and peroxynitrite production  Yoshitaka.

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Presentation on theme: "P-selectin participates in cardiopulmonary bypass–induced inflammatory response in association with nitric oxide and peroxynitrite production  Yoshitaka."— Presentation transcript:

1 P-selectin participates in cardiopulmonary bypass–induced inflammatory response in association with nitric oxide and peroxynitrite production  Yoshitaka Hayashi, MDa, Yoshiki Sawa, MDa, Motonobu Nishimura, MDa, Shinichiro J. Tojo, PhDb, Naoto Fukuyama, MDc, Hiroe Nakazawa, MDc, Hikaru Matsuda, MDa  The Journal of Thoracic and Cardiovascular Surgery  Volume 120, Issue 3, Pages (September 2000) DOI: /mtc Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

2 Fig. 1 A, Relationship between exhaled NO concentration and respiratory index at the termination of CPB (group P: respiratory index = – ± × exhaled NO, r 2 = 0.609; group C: respiratory index = – ± × exhaled NO, r 2 = 0.661). B, Relationship between exhaled NO concentration and respiratory index 3 hours after CPB (group P: respiratory index = – ± × exhaled NO, r 2 = 0.332; group C: respiratory index = – ± × exhaled NO, r 2 = CPB-off, At the termination of CPB; after 3 hrs, 3 hours after the termination of CPB; exhaled NO, exhaled NO concentration. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

3 Fig. 2 Representative histologic findings of lung tissues after CPB. P-selectin expression and neutrophil accumulation in ARP2-4–treated lung tissue were less than in non–ARP2-4 (PNB1.6)–treated lung tissue. A, P-selectin expression in non–ARP2-4–treated lung tissue (group C). B, P-selectin expression was less in ARP2-4–treated lung tissue (group P). C, Neutrophil accumulation in non–ARP2-4–treated lung tissue (group C). D, Neutrophil accumulation was less in ARP2-4–treated lung tissue (group P). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions


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