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Does stimulation with human gonadotropins and gonadotropin-releasing hormone agonist enhance and accelerate the developmental capacity of oocytes in human.

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Presentation on theme: "Does stimulation with human gonadotropins and gonadotropin-releasing hormone agonist enhance and accelerate the developmental capacity of oocytes in human."— Presentation transcript:

1 Does stimulation with human gonadotropins and gonadotropin-releasing hormone agonist enhance and accelerate the developmental capacity of oocytes in human ovarian tissue xenografted into severe combined immunodeficient mice?  Laura Lotz, Heike Schneider, Janina Hackl, M.D., David Wachter, M.D., Inge Hoffmann, M.D., Roland Jurgons, M.D., Matthias W. Beckmann, M.D., Ralf Dittrich, Ph.D.  Fertility and Sterility  Volume 101, Issue 5, Pages e3 (May 2014) DOI: /j.fertnstert Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 A metaphase II oocyte retrieved after 20 weeks of grafting without stimulation (viewed on inverted microscopy; original magnification ×32). Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Effects of graft duration and exogenous stimulation on the primordial follicle pool in the various study groups. Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

4 Supplemental Figure 1 Typical image of human ovarian tissue transplanted into a severe combined immunodeficient mouse, after 24 weeks of grafting. Small vessels are visible on the surface (arrows). Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

5 Supplemental Figure 2 Histologic analysis of ovarian tissue after 4 weeks of xenografting, showing primordial and primary follicles (arrow) with largely intact morphology. Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

6 Supplemental Figure 3 After 24 weeks of grafting, all types of follicles (open arrow indicates an antral follicle; solid arrow indicates a primordial follicle), including antral ones, were observed in the tissue. (Ovarian tissue with follicles stained with hematoxylin-eosin; original magnification ×20). Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

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