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Thirty-Day In-Parallel Artificial Lung Testing in Sheep

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Presentation on theme: "Thirty-Day In-Parallel Artificial Lung Testing in Sheep"— Presentation transcript:

1 Thirty-Day In-Parallel Artificial Lung Testing in Sheep
Hitoshi Sato, MD, Candice M. Hall, BS, LVT, Nathan G. Lafayette, BS, Joshua R. Pohlmann, BS, Niru Padiyar, MD, John M. Toomasian, MS, Jonathan W. Haft, MD, Keith E. Cook, PhD  The Annals of Thoracic Surgery  Volume 84, Issue 4, Pages (October 2007) DOI: /j.athoracsur Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 The MC3 Biolung total artificial lung (TAL) attached to the flank of a sheep. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Mean arterial pressure (mAP, squares) and cardiac output (CO, circles) at baseline (BL) and at days 1 through 30 after total artificial lung attachment. Data are averaged over 3-day periods and presented with the standard deviation. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Artificial lung resistance (circles) and percentage of cardiac output (CO, squares) flowing to the total artificial lung (TAL) for baseline (BL) and at days 1 through 30 post-TAL attachment. Data are averaged over 3-day periods and presented with the standard deviation. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Typical MC3 Biolung after 30 days. Note thrombus formation at the end of the device closest to the inlet and outlet ports. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Total artificial lung (TAL) blood flow (diamonds) and resistance (circles) for a single, representative sheep at baseline (BL) and at days 1 through 30 post-TAL attachment days one through thirty. Data are averaged over 3-day periods. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

7 Fig 6 Counts for platelets (squares) and white blood cells (circles) at baseline (BL) and at days 1 through 30 after total artificial lung attachment. Data are averaged over 3-day periods and presented with the standard deviation. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

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