1. Figure 1 NAFLD pathogenesis
Figure 1 | NAFLD pathogenesis. A combination of genetic factors and environmental factors can influence hepatic steatosis risk. In patients with hepatic steatosis, inflammation is triggered by multiple mechanisms. These processes activate Kuppfer cells and stellate cells, and promote a type 2 T helper (TH2) cell inflammatory response, with progressive fibrosis. NASH can progress to cirrhosis. Hepatocellular carcinoma (HCC) often occurs in the context of NASH cirrhosis but can occur without cirrhosis. Inhibition of activated CD8+ T cells and increased cell proliferation confer increased HCC risk. DNL, de novo lipogenesis; FFA, free fatty acids; IR, insulin resistance; JNK1, c-Jun N-terminal kinase 1; ROS, reactive oxygen species.
Khan, R. S. & Newsome, P. N. (2018) Novel insights into mechanisms of disease progression
Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro