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Increased progesterone receptor expression in uterine leiomyoma: correlation with age, number of leiomyomas, and clinical symptoms  Anastasia Tsigkou,

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Presentation on theme: "Increased progesterone receptor expression in uterine leiomyoma: correlation with age, number of leiomyomas, and clinical symptoms  Anastasia Tsigkou,"— Presentation transcript:

1 Increased progesterone receptor expression in uterine leiomyoma: correlation with age, number of leiomyomas, and clinical symptoms  Anastasia Tsigkou, Ph.D., Fernando M. Reis, M.D., Meng H. Lee, Ph.D., Bingjie Jiang, Ph.D., Claudia Tosti, M.D., Gabriele Centini, M.D., Fang-Rong Shen, M.D., You-Guo Chen, M.D., Felice Petraglia, M.D.  Fertility and Sterility  Volume 104, Issue 1, Pages e1 (July 2015) DOI: /j.fertnstert Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Relative mRNA expression of the progesterone receptors, (A) PR-total and (B) PR-B, and protein levels of (C) PR-A and (D) PR-B in paired samples of human myometrium and uterine leiomyoma. M = molecular weight marker. Data are expressed as median and interquartile range. *P<.05, Wilcoxon test. Fertility and Sterility  , e1DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Relative mRNA expression of progesterone receptor (PR) total and PR-B in leiomyoma samples from women classified according to the number of myomas and age. *P<.05; **P<.01, Mann-Whitney U test. The bottom picture shows Western blot bands of PR-A and PR-B in leiomyoma samples from women up to 40 years old with one to three myomas (lanes 1–2) and women over 40 years-old with more than three myomas (lanes 3–6). Fertility and Sterility  , e1DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

4 Supplemental Figure 1 Nonparametric correlation plots of progesterone receptor B (PR-B) mRNA expression with patient's age (A), number of leiomyomas (B), dysmenorrhea (C), and intermenstrual bleeding (D). r = Spearman's rank correlation coefficient. Fertility and Sterility  , e1DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions


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