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An Unusual Case of Urticaria and Nephrotic Syndrome

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1 An Unusual Case of Urticaria and Nephrotic Syndrome
Michael R. Wiederkehr, MD, Roberto F. Nicosia, MD, Cary Munschauer, Orson W. Moe, MD  American Journal of Kidney Diseases  Volume 48, Issue 3, Pages (September 2006) DOI: /j.ajkd Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions

2 Fig 1 (A) Patient with sudden-onset diffuse urticaria and edema of lips and eyelids. (B, C) Two views of typical urticarial rash: small palpable purplish lesions, measuring just a few millimeters in diameter. American Journal of Kidney Diseases  , DOI: ( /j.ajkd ) Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions

3 Fig 2 (A to C) Light and (D, E) electron micrographs of renal biopsy specimen. Glomeruli stained with (A, C) Jones methenamine silver and (B) periodic acid–Schiff show mildly thickened capillary walls and mesangial stalks. (C) Inset shows finely vacuolated glomerular capillary basement membrane on silver stain. (D, E) Ultrastructural studies show immune-type electron-dense deposits in subepithelial (arrows) and mesangial (*) locations (magnification bars: [A], 200 μm; [B, C], 50 μm; [D, E], 5 μm). American Journal of Kidney Diseases  , DOI: ( /j.ajkd ) Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions

4 Fig 3 (A, B) Light micrographs of skin biopsy specimen stained with hematoxylin and eosin show a vasculitic process involving dermal microvessels (arrows). Inflammatory infiltrates are composed of mononuclear and polymorphonuclear leukocytes (magnification bars: 100 μm). American Journal of Kidney Diseases  , DOI: ( /j.ajkd ) Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions


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