Presentation is loading. Please wait.

Presentation is loading. Please wait.

Harding H. Luan, Ruslan Medzhitov  Cell Metabolism 

Published bySuryadi Atmadjaja Modified over 5 years ago

Similar presentations

Presentation on theme: "Harding H. Luan, Ruslan Medzhitov  Cell Metabolism "— Presentation transcript:

1 Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense 
Harding H. Luan, Ruslan Medzhitov  Cell Metabolism  Volume 24, Issue 3, Pages (September 2016) DOI: /j.cmet Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Role of Itaconate in the Immune Response
(A) IRG1/CAD is induced upon inflammation and converts cis-aconitate to itaconate. Itaconate has direct antimicrobial effects on both intracellular bacteria and extracellular bacteria. Additionally, itaconate can inhibit succinate dehydrogenase activity, leading to decreased ROS production and inflammation. (B) IRG1/CAD decarboxylates cis-aconitate to generate itaconate. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2016 Elsevier Inc. Terms and Conditions

Download ppt "Harding H. Luan, Ruslan Medzhitov  Cell Metabolism "

Similar presentations

How T Cells Earn the Follicular Rite of Passage Carola G. Vinuesa, Jason G. Cyster Immunity Volume 35, Issue 5, Pages 671-680 (November 2011) DOI: 10.1016/j.immuni.2011.11.001.

How T Cells Earn the Follicular Rite of Passage Carola G. Vinuesa, Jason G. Cyster Immunity Volume 35, Issue 5, Pages (November 2011) DOI: /j.immuni
Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages 241-253 (March 2014) DOI: 10.1016/j.cell.2014.02.012 Copyright.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.

The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.
Genetically Encoded Fluorescent Sensors for Intracellular NADH Detection Yuzheng Zhao, Jing Jin, Qingxun Hu, Hai-Meng Zhou, Jing Yi, Zhenhang Yu, Lei Xu,

Genetically Encoded Fluorescent Sensors for Intracellular NADH Detection Yuzheng Zhao, Jing Jin, Qingxun Hu, Hai-Meng Zhou, Jing Yi, Zhenhang Yu, Lei Xu,
What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages 20-44 (January 2014) DOI: 10.1016/j.cell.2013.12.012.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.
Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages 12-24 (July 2010) DOI: 10.1016/j.immuni.2010.07.006.

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni
Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages 226-240 (August 2014) DOI: 10.1016/j.cmet.2014.07.001.

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet
Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages 38-52 (April 2008) DOI: 10.1016/j.cell.2008.03.011.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell
Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.
PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors Joan Sanchez-Gurmaches, Chien-Min.

PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors Joan Sanchez-Gurmaches, Chien-Min.
Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages 1262-1272 (September 2014)

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)
Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages 275-291 (March 2014) DOI: 10.1016/j.stem.2014.02.006.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem
Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages 248-252 (April 2010) DOI: 10.1016/j.cmet.2010.03.008 Copyright © 2010.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.
The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages 558-573 (April.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.
Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.

Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.
Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages 838-850 (June 2013) DOI:

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:
Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages 11-22.

Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages
Septic Shock: On the Importance of Being Tolerant

Septic Shock: On the Importance of Being Tolerant
Approaching the Asymptote: 20 Years Later

Approaching the Asymptote: 20 Years Later

Similar presentations

Ads by Google