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Observer Variability in Mesothelioma Tumor Thickness Measurements: Defining Minimally Measurable Lesions  Samuel G. Armato, PhD, Anna K. Nowak, MD, PhD,

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Presentation on theme: "Observer Variability in Mesothelioma Tumor Thickness Measurements: Defining Minimally Measurable Lesions  Samuel G. Armato, PhD, Anna K. Nowak, MD, PhD,"— Presentation transcript:

1 Observer Variability in Mesothelioma Tumor Thickness Measurements: Defining Minimally Measurable Lesions  Samuel G. Armato, PhD, Anna K. Nowak, MD, PhD, Roslyn J. Francis, MD, PhD, Masha Kocherginsky, PhD, Michael J. Byrne, MD  Journal of Thoracic Oncology  Volume 9, Issue 8, Pages (August 2014) DOI: /JTO Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 A two-dimensional example demonstrates that a 10-mm-diameter circle (representing a spherical tumor) has a much smaller area (volume) than a 10-mm-thick annulus (representing a rind of mesothelioma tumor). Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Examples of selected tumor measurement sites (indicated with “+―) with local morphologies characterized as (A) concave rind, (B) convex rind, (C) convex mass, and (D) fusiform mass. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Observers were independently shown the image with the outer tumor margin point marked (red circle) at each site for measurement. The six observers’ tumor thickness line segments are shown superimposed, with the primary observer measurement arrowed. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 Distribution of the mean tumor thickness measurement across all six observers at each of the 170 measurement sites. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

6 FIGURE 5 Each scatter plot displays, for each of the 170 measurement sites, the relative difference between the measurement of one observer and the average measurement across all other observers as a function of mean measurement at the site. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

7 FIGURE 6 Distribution of the range of tumor thickness measurements across all six observers at each of the 170 sites as a percent of the mean measurement at that site. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

8 FIGURE 7 Distributions of the range of observers’ measurements at each site as a percent of the mean measurement at that site (interobserver variability) categorized by local lesion morphology at the site. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

9 FIGURE 8 Distributions of the difference between the measurement of one observer and the average measurement across all other observers at each site as a percent of the mean measurement at that site aggregated across observers and sites and plotted as a function of mean site measurement. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

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