1. Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver- derived angiotensinogen 
David I. Ortiz-Melo, Robert F. Spurney 
Kidney International 
Volume 85, Issue 5, Pages (May 2014)
DOI: /ki
Copyright © 2014 International Society of Nephrology Terms and Conditions

2. Figure 1
A defect in glomerular permselectivity enhances renal angiotensin II generation. Loss of glomerular filtration barrier integrity permits significant amounts of angiotensinogen and renin into the tubular fluid. With angiotensin-converting enzyme present on the proximal tubule brush border, all the components required for robust angiotensin II generation are present in the tubular lumen. ACE, angiotensin-converting enzyme; AGT, angiotensinogen; Ang II, angiotensin II; AT1R, Ang II type 1 receptor.
Kidney International  , DOI: ( /ki )
Copyright © 2014 International Society of Nephrology Terms and Conditions