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Kirsten M. Kloepfer, MD, MS, Vishal K

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Presentation on theme: "Kirsten M. Kloepfer, MD, MS, Vishal K"— Presentation transcript:

1 Community-acquired rhinovirus infection is associated with changes in the airway microbiome 
Kirsten M. Kloepfer, MD, MS, Vishal K. Sarsani, MS, Valeriy Poroyko, PhD, Wai Ming Lee, PhD, Tressa E. Pappas, BS, Theresa Kang, BS, Kristine A. Grindle, BS, Yury A. Bochkov, PhD, Sarath Chandra Janga, PhD, Robert F. Lemanske, MD, James E. Gern, MD  Journal of Allergy and Clinical Immunology  Volume 140, Issue 1, Pages e8 (July 2017) DOI: /j.jaci Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Relative abundance at the genera level (OTUs >1%) between RV-negative and RV-positive samples in the asymptomatic group (A) and the asthma exacerbation group (B). ∗Significant differences between RV-negative and RV-positive samples. Asymptomatic group: Dolosigranulum q value = 1.4 × 10−8; Corynebacterium q value = 1.5 × 10−111; Moraxella q value = 1.4 × 10−8; unclassified OTU no. 1 q value = 0. Exacerbation group: Corynebacterium q value = 7.8 × 10−25; Moraxella q value = 9.8 × 10−47; unclassified OTU no. 1 q value = 5.9 × 10−50. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig E1 Subject inclusion.
Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E2 Relative abundance at the phylum level and the genera level between RV-negative and RV-positive samples. ∗Significant differences between RV-negative and RV-positive samples. Firmicutes q value = 7.62 × 10−6; Dolosigranulum q value = 1.13 × 10−8; Moraxella q value = 5.5 × 10−7; and unclassified OTU no. 1 q value = 1 × 10−24. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E3 Microbial composition of individual samples. First bar in each pair is uninfected, second bar is RV infected. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E4 Association networks to examine whether a relationship exists between viral load and bacterial abundance. Each line represents an OTU. Green line indicates increase in bacterial abundance as the viral load increases. Red line indicates decrease in abundance as the viral load increases. Size of circle represents the number of sequences associated with that OTU. Node color represents the phyla associated with that OTU. Increasing viral load is associated with decreases in Dolosigranulum, Corynebacterium, Prevotella, Actinomyces, and some OTUs of Streptococcus and Moraxella. However, increased viral shedding is also associated with increases in Haemophilus and other OTUs of Streptococcus and Moraxella. Readers should note the following: (1) the position of each node in the network is user-defined, and (2) the structure of the network does not represent any biological functions. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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