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TNF-Receptor Inhibitor Therapy for the Treatment of Children with Idiopathic Pneumonia Syndrome. A Joint Pediatric Blood and Marrow Transplant Consortium.

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Presentation on theme: "TNF-Receptor Inhibitor Therapy for the Treatment of Children with Idiopathic Pneumonia Syndrome. A Joint Pediatric Blood and Marrow Transplant Consortium."— Presentation transcript:

1 TNF-Receptor Inhibitor Therapy for the Treatment of Children with Idiopathic Pneumonia Syndrome. A Joint Pediatric Blood and Marrow Transplant Consortium and Children's Oncology Group Study (ASCT0521)  Gregory A. Yanik, Stephan A. Grupp, Michael A. Pulsipher, John E. Levine, Kirk R. Schultz, Donna A. Wall, Bryan Langholz, Christopher C. Dvorak, Keith Alangaden, Rakesh K. Goyal, Eric S. White, Jennifer M. Collura, Micah A. Skeens, Saada Eid, Elizabeth M. Pierce, Kenneth R. Cooke  Biology of Blood and Marrow Transplantation  Volume 21, Issue 1, Pages (January 2015) DOI: /j.bbmt Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Overall survival (solid line) and 95% confidence intervals (dashed line) as a function of time since initiation of study therapy. Kaplan-Meier plot. Biology of Blood and Marrow Transplantation  , 67-73DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Plasma biomarkers in IPS. Plasma protein levels were analyzed from patient samples collected at the time of IPS diagnosis (IPS Dx), day 7 (D7), and day 28 (D28) of study. Two control groups were included, (1) healthy, nontransplantation patients, control (NL), and (2) allogeneic transplant recipients without complications, control (BMT). Plasma samples from control (BMT) were analyzed at day 0 and day 14 after transplantation, the day-14 time point chosen to approximate the time of onset of IPS. Data are expressed as mean ± SEM. Significant differences between groups are shown as *P < .05, **P < .01, ***P < .001. Biology of Blood and Marrow Transplantation  , 67-73DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Plasma biomarker levels of IPS at the time of diagnosis and on day 7 of study therapy, in responders and nonresponders. Plasma protein levels were analyzed from patient samples collected at the time of IPS diagnosis (IPS Dx), and on day 7 (D7) of study. Day-7 levels are then subdivided by those patients who responded (Resp) or did not respond (NR) to study therapy. Control samples were obtained on day 14 after transplantation in allogeneic transplant recipients without complications, D14 control (BMT). Data are expressed as mean ± SEM. Significant differences between groups are shown as: *P < .05, **P < .01, ***P < .001. Biology of Blood and Marrow Transplantation  , 67-73DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions


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