1. Antipsychotic drugs

2. Psychotherapeutic drug therapy
Chemical product
Produce effect on the mind ,emotions ,& body
Action of psychotic drugs ;
Nervous system ,disturbe neurotransmitter pathway

4. Frontal lobe responsible for : Love creativity insight planning
judgment
abstract reasoning

5. Limbic system responsible for ;
Emotions,
motivation
memory
fight or flight

6. The drugs affect these area so profound changes in behavior result
Figure 7-1 ( division of the nervous system )
CNS: motor & sensory effect

8. Adrenergic effect : sympathetic effect ( fight or flight )
Increase heart rate
Increase cardiac out put
Dilate pupil
Improve visual acuity
Bronchodilator
More o2 enter to chest
Increase blood sugar & fatty acid
Increase energy
Increase mental activity
Act in case of stress

10. Parasympathetic nervous system ( cholinergic nervous system ) PSN
Acetylcholine neurotransmitter
Regulatory process
Decrease heart rate
Decrease blood volume
Decrease cardiac out put
Relax sphincter
Increase body secretion

11. Cell of nervous system is neuron ,its function : transmit electrical information to other neuron
Neuron produce chemical substance called neurotransmitter
No connection between neurons
The space between neuron & other is called synape

12. Classification of neurotransmitter
Monoamines
Cholinergic
Amino acids
Neuropeptide

13. Classification of psychotropic drugs
Antianxiety
Antidepressant
Antimanics
Antipsychotic

14. Ant anxiety medication :
Anxietyis common mental health problem
These drugs named anxiolytics or minor tranquilizer
benzodiazepines ( hypnotic )
-provide sedation
Induce sleep
Prevent seizures
Prepare for general anasthesia

15. Decrease anxiety
Act fast within 1 hour
Duration4 -6hours
Metabolism in the river
Excreted by kidney
Avoid in pregnancy & lactation
Side effect : fatigue ,sedation ,dizziness, orthostatic hypotension & dependency
Eg.buspirone (buspar) cause addiction
-pregabalin (lyrica)
Don’t use antacid with anxiolytic drugs it will impair its absorption

16. Antidepressant medication :
Uses in affective disorder : many of human being their life is mixture of happiness & sadness & the human adapted with his feeling ,but when these emotions affect his productivity & unable to fight his environment with failure of adaptation to life he become diseased
Types of antidepressant
tricyclic antidepressant drugs
selective seretonine inhibitor
MAOIs

17. Indications: 1-depression –manic –panic
2-OCD (obsessive compulsive disorder )
3-enuresis (bed wetting )
4-bulimia
5-neuropathic pain
6-PISD post traumatic stress disorder
7- attention deficit hyperactivity disorder

18. MAOIs
will increase blood pressure , the diet should be free from cheese & its product
This drug need 4 weeks to be act effectively
Side effect of MAOIs;
Dry mouth ,nose ,eye
Hypertensive crisis
Urine retention
Sedation

19. Antimanic medication Characteristic of manic disorder include
1- excitement
2-great elation
3-over talkativeness
4-increase motor activity
5-feeling grandiose idea
6-agitated behavior

20. Example : lithium
Uses:-mania
Bipolar
Drug abuse
Alcoholism
Phobias
Eating disorder

21. Contraindication of lithium;
Pregnant woman
Kidney disease
Lithium toxicity if blood level is more than 1.5 MEq\l
Need 3 week to act & to be effective
Long term used of lithium will cause hypothyroidism
,& inability of the kidney to concentrate urine
Another medication : tegretol ,valporic acid (depakein )

22. Before giving lithium;
1- complete history
2-hysical examination
3-ECG
4-blood studies

23. Antipsychotic : neuroleptic medications or major tranquilizer
* tablet * liquid *injection
Uses ;
Schizophrenia
Acute mania
Organic mental illness
Paranoid
Manic –depressive
Movement disorder
Nausea & vomiting
Intractable hiccough

24. Eg. Haloperidol ( haledol )
Side effect of antipsychotic drugs;
Extrapyramidal side effect ( EPSEs)
Abnormal movement produced by imbalance of neurotransmitter in the brain
Which include

25. Dry mouth
Blurred vision
Photophobia : sensitivity to bright light
Tachy cardia
Hypotension
Lookbooks (7-6) EPSEs of antipsychotic drugs
Loof for table 7-6 (teaching guidelines psychotropic medications )