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The INFUSE-Morphine Study: Use of Recombinant Human Hyaluronidase (rHuPH20) to Enhance the Absorption of Subcutaneously Administered Morphine in Patients.

Published byLadislava Müllerová Modified over 5 years ago

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Presentation on theme: "The INFUSE-Morphine Study: Use of Recombinant Human Hyaluronidase (rHuPH20) to Enhance the Absorption of Subcutaneously Administered Morphine in Patients."— Presentation transcript:

1 The INFUSE-Morphine Study: Use of Recombinant Human Hyaluronidase (rHuPH20) to Enhance the Absorption of Subcutaneously Administered Morphine in Patients with Advanced Illness  Jay R. Thomas, MD, PhD, Mark S. Wallace, MD, Richard C. Yocum, MD, Daniel E. Vaughn, PhD, Michael F. Haller, PhD, Jocelyne Flament, MD  Journal of Pain and Symptom Management  Volume 38, Issue 5, Pages (November 2009) DOI: /j.jpainsymman Copyright © Terms and Conditions

2 Fig. 1 Randomized sequence of injections. A, intravenous morphine; B, subcutaneous morphine with placebo; C, subcutaneous morphine with rHuPH20. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © Terms and Conditions

3 Fig. 2 Tmax (mean ± SD) and Cmax (geometric mean ± DS) of morphine for each administration method. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © Terms and Conditions

4 Fig. 3 Pharmacokinetic curves for morphine plasma concentration over four hours postinjection (population means ± SDs) for each administration method. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © Terms and Conditions

5 Fig. 4 Pharmacokinetic curves for morphine plasma concentration over the first 30minutes postinjection (population means ± SDs) for each administration method. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © Terms and Conditions

6 Fig. 5 Morphine AUC0−t (geometric mean +/− DS) for each administration method. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © Terms and Conditions

7 Fig. 6 Scores for severity of a) injection-site edema, (0 = none, 1 = minimal, 2 = mild, 3 = moderate, 4 = severe) b) rash (0 = none, 1 = minimal, 2 = mild, 3 = moderate, 4 = severe), and c) discomfort (0 = no discomfort, 100 = worst possible discomfort [100 mm VAS scale]). Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © Terms and Conditions

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