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Regulation of the Wnt/b-catenin pathway by redox signaling.

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Presentation on theme: "Regulation of the Wnt/b-catenin pathway by redox signaling."— Presentation transcript:

1 Regulation of the Wnt/b-catenin pathway by redox signaling.
Funato Y. et al. Nat Cell Biol. 8(5): (2006)

2 NEDL-1 Miyazaki K. et al. J Biol Chem. 279(12): (2004)

3 Inversin Simons M. et al. Nat Genet. 37(5): (2005)

4 KLHL12-Cullin-3 Angers S. et al. Nat Cell Biol. 8(4): (2006)

5 Dapper-1 Zhang L. et al. J Biol Chem. 281(13): (2006)

6 Thioredoxin Powis G. et al. Annu. Rev. Biophys. Biomol. Struct. 30:421–55. (2001)

7 Redox-dependent association between Dvl and NRX

8 Redox-dependent association between Dvl and NRX

9 Redox-dependent association between Dvl and NRX

10 NRX supresses Wnt/b-catenin signalling

11 NRX supresses Wnt/b-catenin signaling

12 NRX RNAi shows TCF activation and increased cell proliferation

13 Competition between NRX and Frat for Dvl

14 NRX inhibits Wnt/b-catenin signaling in Xenopus

15 NRX inhibits Wnt/b-catenin signaling in Xenopus

16 Activation of the Wnt/b-catenin pathway by H2O2


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