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A Rare Central Thoracic Tumor

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Presentation on theme: "A Rare Central Thoracic Tumor"— Presentation transcript:

1 A Rare Central Thoracic Tumor
Kristof Cuppens, MD, Marion Delcroix, MD, PhD, Dirk Van Raemdonck, MD, PhD, Bart Meyns, MD, PhD, Rafael Sciot, MD, PhD, Maria Debiec-Rychter, MD, PhD, Johan F. Vansteenkiste, MD, PhD  Journal of Thoracic Oncology  Volume 9, Issue 6, Pages (June 2014) DOI: /JTO Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Transaxial chest computed tomography images (A) show a mass invading the right pulmonary artery and mediastinum and a central filling defect in the proximal left pulmonary artery (arrow). The mass had moderate 18F-fluorodeoxyglucose uptake on positron emission tomography (B). Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Resection specimen showing tumor occluding the right pulmonary artery (A) and a pale pulmonary artery cast after left pulmonary endarterectomy (B). Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Histopathological examination. Low power view (A) showing the tumor nodules in the arterial branches (arrows), and at higher magnification (B), a moderately cellular spindle cell proliferation is present. Immunohistochemistry showing nuclear MDM2 expression (C) and strong cytoplasmic epidermal growth factor receptor labeling (D). Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

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