1. Somatic Hypermutation, Transcription, and DNA Mismatch Repair
Margrit Wiesendanger, Matthew D Scharff, Winfried Edelmann 
Cell 
Volume 94, Issue 4, Pages (August 1998)
DOI: /S (00)

2. Figure 1 Proposed Model for Somatic Hypermutation
When the Ig gene is transcribed, an accessibility factor (A) allows a putative mutator factor (M) to generate base mismatches, pictured as yellow triangles. These base mismatches are shown occurring on both strands, but this issue has yet to be fully resolved. In a subsequent step, the MMR complex assembles and repairs some of the mismatches. In the next round of DNA replication, these mutations will be fixed into the genome. This model draws upon various aspects of the proposals of Kolodner, Storb, Neuberger and Milstein, and their colleagues (Kolodner 1996; Neuberger et al. 1998; Storb et al. 1998).
Cell  , DOI: ( /S (00) )