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Fig. 2 Analysis of CLL lymph nodes.

Published byMegan Nicholson Modified over 5 years ago

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Presentation on theme: "Fig. 2 Analysis of CLL lymph nodes."— Presentation transcript:

1 Fig. 2 Analysis of CLL lymph nodes.
Analysis of CLL lymph nodes. (A) Two representative cases (of the 16 examined) expressing low (n = 10) or high (n = 6) IL-23R chain (magnification, ×200). (B) Double-marker immunofluorescence (IF) analysis of IL-23R chain (left) or IL-12Rβ1 chain (right) and CD20 in a representative lymph node displaying high expression of the IL-23R chain (n = 6 of 16) (magnification, ×200). (C) Double-marker IF analysis of IL-23R and IL-12Rβ1 showing foci of higher and lower IL-12Rβ1 expression (dashed circles; magnification, ×100). (D) Double-marker IF analysis of IL-12Rβ1 and CD68 showing higher expression of IL-12Rβ1 in foci with higher CD68-expressing cell density. (E) Double-marker IF analysis showing different representative areas of the same lymph node with lower (top) and higher (bottom) IL-12Rβ1 expression and corresponding CD40L expression (magnification, ×200). (B to E) Microphotographs are relative to one representative lymph node (of six evaluated) displaying IL-23Rhigh chain. IF microphotographs are representative of analyses on at least 5 for low-power magnification (×100) or 10 for high-power magnification (×200 and ×400) microscopic fields performed on each lymph node sample. Giovanna Cutrona et al., Sci Transl Med 2018;10:eaal1571 Published by AAAS

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