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Prenatal initiation of endotoxin airway exposure prevents subsequent allergen-induced sensitization and airway inflammation in mice  Kerstin Gerhold,

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Presentation on theme: "Prenatal initiation of endotoxin airway exposure prevents subsequent allergen-induced sensitization and airway inflammation in mice  Kerstin Gerhold,"— Presentation transcript:

1 Prenatal initiation of endotoxin airway exposure prevents subsequent allergen-induced sensitization and airway inflammation in mice  Kerstin Gerhold, MD, Angela Avagyan, Christine Seib, MD, Remo Frei, Johanna Steinle, Birgit Ahrens, MD, Anna-Maria Dittrich, MD, Katharina Blumchen, MD, Roger Lauener, MD, Eckard Hamelmann, MD  Journal of Allergy and Clinical Immunology  Volume 118, Issue 3, Pages (September 2006) DOI: /j.jaci Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Effects of prenatal LPS exposure on allergen-mediated AI and AR. After prenatal with or without postnatal LPS exposure in OVA- and placebo-sensitized mice that underwent allergen challenge, AI was examined by means of differentiation of leukocytes and IL-5 levels in bronchoalveolar lavage fluids (A) and in vivo AR by means of whole-body plethysmography in response to MCh (B). ∗P < .05 versus negative control animals; †P < .05 versus OVA-sensitized positive control animals. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions


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