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Increased Immune Reactivity Predicts Aggressive Complicating Crohn's Disease in Children  Marla C. Dubinsky, Subra Kugathasan, Ling Mei, Yoana Picornell,

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Presentation on theme: "Increased Immune Reactivity Predicts Aggressive Complicating Crohn's Disease in Children  Marla C. Dubinsky, Subra Kugathasan, Ling Mei, Yoana Picornell,"— Presentation transcript:

1 Increased Immune Reactivity Predicts Aggressive Complicating Crohn's Disease in Children 
Marla C. Dubinsky, Subra Kugathasan, Ling Mei, Yoana Picornell, Justin Nebel, Iwona Wrobel, Antonio Quiros, Gary Silber, Ghassan Wahbeh, Lirona Katzir, Eric Vasiliauskas, Ron Bahar, Anthony Otley, David Mack, Jonathan Evans, Joel Rosh, Maria Oliva Hemker, Neal Leleiko, Wallace Crandall, Christine Langton, Carol Landers, Kent D. Taylor, Stephan R. Targan, Jerome I. Rotter, James Markowitz, Jeffrey Hyams  Clinical Gastroenterology and Hepatology  Volume 6, Issue 10, Pages (October 2008) DOI: /j.cgh Copyright © 2008 AGA Institute Terms and Conditions

2 Figure 1 (A) Frequency of NPNS, IP/S, and surgery among the different antibody sum groups. P trend < (B) Frequency of NPNS, IP, S, and surgery among the different quartile sum score groups; P trend <.0001. Clinical Gastroenterology and Hepatology 2008 6, DOI: ( /j.cgh ) Copyright © 2008 AGA Institute Terms and Conditions

3 Figure 2 (A) Survival estimates for IP/S by antibody sum 0, vs 1, vs 2, vs 3 (prospective patients only); P < (B) Survival estimates for CD-related surgery by antibody sum 0, vs 1, vs 2, vs 3 (prospective patients only); P < (C) Survival estimates for IP/S by quartile sum score (QSS) group 1, vs 2, vs 3, vs 4 (prospective patients only); P < (D) Survival estimates for CD-related surgery by QSS group 1, vs 2, vs 3, vs 4 (prospective patients only); P < Clinical Gastroenterology and Hepatology 2008 6, DOI: ( /j.cgh ) Copyright © 2008 AGA Institute Terms and Conditions

4 Figure 3 (A) Survival estimates for IP/S by antibody sum 0, vs 1, vs 2, vs 3 (all patients); P < (B) Survival estimates for IP/S by quartile sum score (QSS) group 1, vs 2, vs 3, vs 4 (all patients); P < Clinical Gastroenterology and Hepatology 2008 6, DOI: ( /j.cgh ) Copyright © 2008 AGA Institute Terms and Conditions


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